Mineral Oil Hydrocarbons (MOH) in Food & FCM – Toxicological Evaluation and New Analytical approach for Risk Assessment
Thursday 26th November 2020 – 11,00 am CET
Mineral Oil Hydrocarbons are undesired substances that could be present into food cause of accidental contamination, migration from contact materials or the use processing aids. The risk assessment on the possible risk for public health is challenging both for the complexity of the methods of analysis and their standardization on different matrices and for the difficulty of establishing a toxicological reference point to characterise the hazard. The purpose of the webinar is to provide some strategies useful to face MOH issue from toxicological and analytical point of view.
Chair | Giorgia Purcaro | Analytical Chemistry Professor at Gembloux Agro-Bio Tech University of Liege, Vice-Chair for the Mineral Oil Working Group in ILSI
session 1 | Regulatory principles of Toxicological Evaluation and Risk Assessment | Antonio Conto, Chemsafe Managing Director and ERT (European Registered Toxicologist)
He will introduce and describe the general principles of the hazard assessment in order to define the toxicological profile of a chemical substance which is an intrinsic property of the chemical structure. The approach consists of collecting/evaluating a number of data (literature, experimental and predicted) using a weight of evidence approach to be able to define the hazard properties. The toxicological profile of the substance is the first step to carry out its risk for human health and/or the environment. Risk Assessment means to related/study the hazard with the exposure of the given chemical substance. The final goal is to determine the level of risk and adopt risk mitigation measures when possible. A final part will be dedicated to describe such activity in the context of the Food Contact Material Regulations.
session 2 | Quantitative analysis of MOSH & MOAH by LC-GC-FID | Valeria Mazzoni, Neotron Analytical Chemist
Mineral Oil Hydrocarbons (MOH) comprise a large group of mixtures of hydrocarbons containing thousands of chemical compounds of different structures and size, derived mainly from crude oil but also produced synthetically from coal, natural gas and biomass. MOH consist of MOSH (mineral oil saturated hydrocarbons) and MOAH (mineral oil aromatic hydrocarbons), acronyms of a complex mixture of chemical compounds. This speech will be concerned on the LC-GC-FID hyphenate technique, considered as the gold standard for the MOSH/MOAH quantitative analysis, with a focus on the possibilities of automation.
session 3 | Application of Comprehensive GCxGC for Mineral Oil characterization | Roberto Ronzoni, Neotron Head of Food Contact Materials Testing Lab
Since FID is not a selective detector, two-dimensional gaschromatography (GCxGC) separation coupled with mass spectrometry can be applied as confirmatory technique for characterization of MOSH and/or MOAH. This presentation will introduce the potential of this qualitative technique detecting typical marker substances and performing a more in-depth analysis of food or food contact materials to investigate positive results.